Endotheliopathy

Any disease of the endothelium. In trauma patients, endotheliopathy accompanies shock states in a condition known as traumatic endotheliopathy, the endotheliopathy of trauma, or EoT. EoT is a complex process of endothelial cell injury, activation, and maladaptive responses to major injuries, including tissue trauma, hemorrhagic shock, and burns. EoT causes systemic microvascular thrombosis, inflammation, loss of barrier integrity, and coagulopathy, all of which are hallmarks of traumatic organ failure. PRONUNCIATION: en-do-THE-li-OP-pathy.