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Glossary
Overwhelming post-splenectomy infection (OPSI)
Overwhelming post-splenectomy infection (OPSI)
June 3, 2026
by
TCAR Education Programs, Stephen Von Weller
A rapidly fatal infection occurring in individuals following removal of the spleen, often years or decades after splenectomy. Also known as overwhelming post-splenectomy sepsis (OPSS).
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